Sci Transl Med. Bilateral treatment effect following unilateral injection of gene therapy for ND4-LHON was independently reported by three research groupsLUMEVOQ® is the first gene therapy treating a mitochondrial disease for which marketing approval has been requested from the European Medicines AgencyPARIS--(BUSINESS WIRE)--Regulatory News:GenSight Biologics (Euronext: SIGHT, ISIN: FR0013183985, PEA-PME . 2020 Dec 9;12(573):eaaz7423. Regulatory News: GenSight Biologics (Euronext: SIGHT, ISIN: FR0013183985, PEA-PME eligible), a biopharma company focused on developing and commercializing innovative gene therapies for retinal neurodegenerative diseases and central nervous system disorders, today announced that oral presentations on LUMEVOQ ® and GS030 will be featured at the 2021 ASRS and ESGCT meetings in October. The optronic light‑stimulating goggles (GS030-MD) encode the visual scene in real-time and project a light beam with a specific wavelength and intensity onto the treated retina. By browsing this website, you indicate your acceptance of the use of such cookies, https://www.nature.com/articles/s41591-021-01351-4, First peer-reviewed publication to document partial visual recovery in a blind patient with late-stage inherited retinal disease, GS030 treatment combining gene therapy with light-stimulating medical device enabled patient with 40-year history of retinitis pigmentosa to regain ability to perceive, locate, count and touch objects, Electroencephalographic (EEG) readings during visual tests suggest task-related activity in the visual cortex, Video showing patient successfully performing visual tests available on www.gensight-biologics.com. Bilateral visual improvement with unilateral gene therapy injection for Leber hereditary optic neuropathy. As per protocol, three cohorts with three subjects each will be administered an increasing dose of GS030-DP via a single intravitreal injection in their worse-seeing eye. Merck announced on Wednesday a supply and purchase agreement that will provide Singapore with access to its experimental oral COVID-19 antiviral drug, the latest Asian country to try to snap up supplies. The week’s first session was painted a deep red, but you’d be hard-pressed to find a Xenon Pharmaceuticals (XENE) investor concerned with Monday’s bloodbath. The Price to Earnings (P/E) ratio, a key valuation measure, is calculated by dividing the stock's most recent closing price by the sum of the diluted earnings . 06-10-2021. Launched in 2014 . A high-level overview of GenSight Biologics S.A. (GSGTF) stock. PARIS, October 06, 2021--(BUSINESS WIRE)--Regulatory News: GenSight Biologics (Euronext: SIGHT, ISIN: FR0013183985, PEA-PME eligible), a biopharma company focused on developing and commercializing innovative gene therapies for retinal neurodegenerative diseases and central nervous system disorders, today announced that the peer-reviewed journal International Ophthalmology Clinics has published a review of current and past gene therapy clinical trials for the treatment of Leber hereditary optic neuropathy (LHON). The success rate was similar for objects at different contrasts, suggesting that even objects at lower contrasts generated enough retinal activity for perception. Bilateral visual improvement with unilateral gene therapy injection for Leber hereditary optic neuropathy. The company expects to file the request, called a marketing authorization application (MAA), in September. Epub ahead of print. Paris, France, May 25, 2021, 7:30 am CEST – GenSight Biologics (Euronext: SIGHT, ISIN: FR0013183985, PEA-PME eligible), a biopharma company focused on developing and commercializing innovative gene therapies for retinal neurodegenerative diseases and central nervous system disorders, today announced that the highly-regarded journal Nature Medicine has published the first case report of partial recovery of visual function in a blind patient with late stage retinitis pigmentosa (RP). Big pharma companies Merck (NYSE: MRK) and Pfizer (NYSE: PFE) have been neck and neck in the most recent coronavirus race: the race to develop a pill to fight the virus. Details will be announced at a later date. Sign-up to receive the latest news and ratings for GenSight Biologics and its competitors with MarketBeat's FREE daily newsletter. Only GenSight’s gene therapy, LUMEVOQ®, has completed Phase III trials and reached the registration phase. Over 100 genetic defects have been implicated. Yu-Wai-Man P, Newman NJ, Carelli V, Moster ML, Biousse V, Sadun AA, Klopstock T, Vignal-Clermont C, Sergott RC, Rudolph G, La Morgia C, Karanjia R, Taiel M, Blouin L, Burguière P, Smits G, Chevalier C, Masonson H, Salermo Y, Katz B, Picaud S, Calkins DJ, Sahel JA. An extension cohort will receive the highest tolerated dose. "We at GenSight Biologics are excited to be at the forefront of these efforts, particularly in Europe where we are already in the registration phase, aiming to bring a therapeutic solution to these patients in 2022.". PARIS--(BUSINESS WIRE)--Regulatory News: GenSight Biologics (Euronext: SIGHT, ISIN: FR0013183985, PEA-PME eligible) (Paris:SIGHT) (the "Company" or "GenSight"), a biopharma company focused on . GenSight Biologics (Paris:SIGHT)(Euronext: SIGHT, ISIN: FR0013183985, PEA-PME eligible), a biopharma company focused on developing and commercializing innovative gene therapies for retinal neurodegenerative diseases and central nervous system disorders, today announced that the Journalof Neuro-Ophthalmology ( JNO) has published results from . Trouvé à l'intérieur – Page 1909Un demi-siècle tout rond ! Expect to see data this month from several clinical trials that are trying to establish if “mixing and matching” different COVID-19 vaccines is safe and effective or if it’s better to get the same booster as the one used in the primary series of shots. Finally, the success rate was similar for the different tasks of perceiving, locating, and touching, suggesting that once the object was perceived, the patient could coordinate his motor system with the percept. Find real-time GSGTF - Gensight Biologics SA stock quotes, company profile, news and forecasts from CNN Business. “This invited review provides a global perspective on the current gene-based approaches developed to tackle this devastating disease and discusses the positive outcomes observed with LUMEVOQ during the recent trials, bringing hope to our patients”, commented lead author José-Alain Sahel, MD,  Distinguished Professor and Chairman of the Department of Ophthalmology at the University of Pittsburgh School of Medicine and UPMC (University of Pittsburgh Medical Center), USA; Co-founder of GenSight Biologics; and Founder of the Institut de la Vision (Sorbonne-Université/Inserm/CNRS), Paris, France, which developed and patented the Mitochondrial Targeted Sequence (MTS) technology used in LUMEVOQ®. PARIS--(BUSINESS WIRE)-- Regulatory News: GenSight Biologics (Paris: SIGHT) (Euronext: SIGHT, ISIN: FR0013183985, PEA-PME eligible), a biopharma company focused on developing and commercializing . (Bloomberg) -- Over the last decade, Vertex Pharmaceuticals Inc. has transformed cystic fibrosis from a debilitating lung disease to a manageable condition for most people who suffer from the inherited ailment. Paris, France, October 6, 2021, 7:30 am CET - GenSight Biologics (Euronext: SIGHT, ISIN: FR0013183985, PEA-PME eligible), a biopharma company focused on developing and commercializing innovative gene therapies for retinal neurodegenerative diseases and central nervous system disorders, today announced that the peer-reviewed journal International Ophthalmology Clinics has published a review . PARIS--(BUSINESS WIRE)-- Regulatory News:GenSight Biologics (Paris:SIGHT) (Euronext: SIGHT, ISIN: FR0013183985, PEA-PME eligible), a biopharma company focused on developing and commercializing innovative gene therapies for retinal neurodegenerative diseases and central nervous system disorders, today announced that the French Competent Authority, the National Agency for Medicines and Health . The success rate with the goggles stimulating the treated eyes was statistically significantly higher than without the goggles (41% vs. 6%; p < 0.001). Regulatory News: GenSight Biologics (Paris:SIGHT)(Euronext: SIGHT, ISIN: FR0013183985, PEA-PME eligible), a biopharma company focused on developing an a. Newman NJ, Carelli V, Taiel M, Yu-Wai-Man P. Visual Outcomes in Leber Hereditary Optic Neuropathy Patients With the m.11778G>A (MTND4) Mitochondrial DNA Mutation. Regulatory News: GenSight Biologics (Euronext: SIGHT, ISIN: FR0013183985, PEA-PME eligible), a biopharma company focused on developing and commercializing innovative gene therapies for retinal . PARIS, September 15, 2021--Regulatory News: GenSight Biologics (Euronext: SIGHT, ISIN: FR0013183985, PEA-PME eligible), a biopharma company focused on developing and commercializing innovative . Results of the First International Workshop. Only GenSight’s gene therapy, LUMEVOQ®, has completed Phase III trials and reached the registration phase. “Watching a patient benefit for the first time from this trial using optogenetics to treat blindness has been a uniquely rewarding experience,” commented Dr. José-Alain Sahel, MD, PhD, lead and co-corresponding author, Co-Founder of GenSight, and Founder of the Institut de la Vision (Sorbonne-Université/Inserm/CNRS), Paris, France. GenSight Biologics (Euronext: SIGHT, ISIN: FR0013183985, PEA-PME eligible), a biopharma company focused on developing and commercializing innovative gene therapies for retinal neurodegenerative diseases and central nervous system disorders, today announced that the Journalof Neuro-Ophthalmology has published a paper on a cross-sectional analysis of the baseline (pre-treatment) characteristics . Mozart compose à Vienne, en 1785, la Fantaisie en ut mineur K.475 pour piano. Optogenetics is a biological technique that involves the transfer of a gene encoding for a light sensitive protein to cause neuronal cells to respond to light stimulation. Incroyables Cétacés ! Ces mammifères ont peuplé fleuves et océans au cours d'une histoire évolutive restée longtemps énigmatique. The paper is available at https://pubmed.ncbi.nlm.nih.gov/34584057/. GSGTF | Complete GenSight Biologics S.A. stock news by MarketWatch. Three cohorts with three subjects each will be administered an increasing dose of GS030-DP via a single intravitreal injection in their worse-seeing eye. News GenSight Biologics S.A.SIGHT. Seven months after the start of his training, he began to report signs of visual improvement. Leap Therapeutics stock shot higher in response to positive data for its cancer drug candidate, DKN-01. Dr. Sahel and Dr. Roska will discuss the case report on a KOL webcast dedicated to Optogenetics and GS030 and hosted by GenSight Biologics. The gene of interest is transferred into the cell to be expressed and produces the functional protein, which will then be shuttled to the mitochondria through specific nucleotidic sequences in order to restore the missing or deficient mitochondrial function. French gene therapy company GenSight Biologics was 32% down on its value at the end of last week by Wednesday…. PARIS--(BUSINESS WIRE)-- Regulatory News:GenSight Biologics (Euronext: SIGHT, ISIN: FR0013183985, PEA-PME eligible), a biopharma company focused on developing and commercializing innovative gene therapies for retinal neurodegenerative diseases and central nervous system disorders, today announced that the peer-reviewed journal International Ophthalmology Clinics has published a review of . 2021 Mar;35(2):201-214. d. Yu-Wai-Man P, Newman NJ, Carelli V, Moster ML, Biousse V, Sadun AA, Klopstock T, Vignal-Clermont C, Sergott RC, Rudolph G, La Morgia C, Karanjia R, Taiel M, Blouin L, Burguière P, Smits G, Chevalier C, Masonson H, Salermo Y, Katz B, Picaud S, Calkins DJ, Sahel JA. 23 Department of Ophthalmology, The University of Pittsburgh School of Medicine, Pittsburgh, USA GenSight Biologics (Euronext: SIGHT, ISIN: FR0013183985, PEA-PME eligible), a biopharma company focused on developing and commercializing innovative gene therapies for retinal neurodegenerative diseases and central nervous system disorders, today announced that the Journal of Neuro-Ophthalmology has published a paper on a cross-sectional analysis of the baseline (pre-treatment) characteristics . Optogenetics combines (1) the use of gene therapy methods to transfer a gene into target neurons with (2) the use of optics and electronics (optronics) to deliver the light to the transduced cells. Ophthalmology. Regulatory News: GenSight Biologics . PARIS--(BUSINESS WIRE)--Regulatory News: GenSight Biologics (Euronext: SIGHT, ISIN: FR0013183985, PEA-PME eligible), a biopharma company focused on developing and commercializing innovative gene . Article. GenSight Biologics’ lead product candidate, LUMEVOQ® (GS010; lenadogene nolparvovec), has been submitted for marketing approval in Europe for the treatment of Leber Hereditary Optic Neuropathy (LHON), a rare mitochondrial disease affecting primarily teens and young adults that leads to irreversible blindness. Sous ce titre, l'auteur a rassemblé les éléments de deux volumes, Le Pain de chaque jour et L'Echelle de Jacob, qui sont aujourd'hui introuvables. Eligible patients in the first three cohorts are those affected by end-stage non-syndromic RP with no light perception (NLP) or light perception (LP) levels of visual acuity. LHON is associated with painless, sudden loss of central vision in the 1st eye, with the 2nd eye sequentially impaired. Regulatory News: GenSight Biologics (Euronext: SIGHT, ISIN: FR0013183985, PEA-PME eligible), a biopharma company focused on discovering and developing GenSight Biologics (Paris:SIGHT) (Euronext: SIGHT, ISIN: FR0013183985, PEA-PME eligible), a biopharma company focused on developing and commercializing innovative gene therapies for retinal neurodegenerative diseases and central nervous system disorders, today announced that its gene therapy LUMEVOQ . Safety data from all the trials so far indicate that intravitreal injection constitutes a safe and easy route of administration, avoiding the complications of sub-retinal surgery. 20 Medical Consultant, GenSight Biologics, USA. LUMEVOQ® (GS010; lenadogene nolparvovec) targets Leber Hereditary Optic Neuropathy (LHON) by leveraging a mitochondrial targeting sequence (MTS) proprietary technology platform, arising from research conducted at the Institut de la Vision in Paris, which, when associated with the gene of interest, allows the platform to specifically address defects inside the mitochondria using an AAV vector (Adeno-Associated Virus). The analysis showed that the vaccine's effectiveness in preventing hospitalization and death remained high at 90% for at least six months, even against the highly contagious Delta variant of the coronavirus. The drugmaker is evaluating its oral antiviral therapy PF-07321332 in a couple of phase 2/3 studies, one in treating COVID-19 patients and another as post-exposure prophylaxis. LHON REALITY Study Group. The primary outcome analysis will be the safety and tolerability at one year post-injection. Merck May Beat Pfizer to the COVID Pill Market. GenSight Biologics’ pipeline leverages two core technology platforms, the Mitochondrial Targeting Sequence (MTS) and optogenetics, to help preserve or restore vision in patients suffering from blinding retinal diseases. The bad news is that no vaccine is 100% effective, and breakthrough cases do happen, especial. All gene therapies investigated provide excellent systemic tolerability and mostly mild ocular side effects, responsive to conventional ophthalmologic treatments. J Neuroophthalmol. Regulatory News: GenSight . Our company news sentiment scores track the average news sentiment of articles about each company over the most recent 7 days in order to identify companies that are receiving positive press. GenSight Biologics’ pipeline leverages two core technology platforms, the Mitochondrial Targeting Sequence (MTS) and optogenetics, to help preserve or restore vision in patients suffering from blinding retinal diseases. GenSight Biologics S.A. is a clinical-stage biopharma company focused on developing and commercializing innovative gene therapies for retinal neurodegenerative diseases and central nervous system disorders. “These could not have occurred without the close collaboration we enjoyed with our partners at the Institut de la Vision, the Institute of Ophthalmology Basel and Streetlab. 2021 May;128(5):649-660. We will now accelerate the GS030 program to make it our second product to reach the market after LUMEVOQ.”. GenSight Biologics (Euronext: SIGHT, ISIN: FR0013183985, PEA-PME eligible), a biopharma company focused on developing and commercializing innovative gene therapies for retinal neurodegenerative diseases and central nervous system disorders, today announced that the independent Data Safety Monitoring Board (DSMB) completed its third safety review of the ongoing PIONEER Phase I/II clinical trial . Trouvé à l'intérieur – Page 149... receives research support from Santhera Pharmaceuticals and GenSight Biologics. ... WHO. https://www.who.int/news-room/fact-sheets/detail/blindness-and- ... “It was breathtaking to witness the first recovery of some visual function in a blind patient,” commented Dr. Botond Roska, MD, PhD, last and co-corresponding author and a pioneer in the field of optogenetic vision restoration. Concerning GenSight Biologics. The estimated incidence of LHON is approximately 800-1,200 new patients who lose their sight every year in the United States and the European Union. XENE shares more than doubled after the biotech released highly positive results from a mid-stage clinical trial. Get the latest Gensight Biologics SA (SIGHT) real-time quote, historical performance, charts, and other financial information to help you make more informed trading and investment decisions. As a neuromodulation method, it can be used to modify or control the activities of individual neurons in living tissue and even in-vivo, with a very high spatial and temporal resolution. The DSMB will review the safety data of all treated subjects in each cohort and will make recommendations before a new cohort receives the next dose. About GenSight Biologics . e. Newman NJ, Yu-Wai-Man P, Carelli V, Moster ML, Biousse V, Vignal-Clermont C, Sergott RC, Klopstock T, Sadun AA, Barboni P, DeBusk AA, Girmens JF, Rudolph G, Karanjia R, Taiel M, Blouin L, Smits G, Katz B, Sahel JA; LHON Study Group. Ophthalmology. "The connection is especially clear when it comes to Moderna's vaccine Spikevax, especially after the second dose," the agency said. RP is the most widespread hereditary cause of blindness in developed nations, with a prevalence of about 1.5 million people throughout the world. 06-02-2019. GenSight Biologics (Paris:SIGHT)(Euronext: SIGHT, ISIN: FR0013183985, PEA-PME eligible), a biopharma company focused on developing and commercializing innovative gene therapies for retinal neurodegenerative diseases and central nervous system disorders, today announced that the Journal of Neuro-Ophthalmology (JNO) has published results from RESTORE, the long-term follow-up study of LUMEVOQ . GENSIGHT BIOLOGICS S.A. : News, information and stories for GENSIGHT BIOLOGICS S.A. | Euronext Paris: SIGHT | Euronext Paris GS030 uses an optimized viral vector (GS030-DP) to express the light-sensitive opsin ChrimsonR in retinal ganglion cells and proprietary light-stimulating goggles (GS030-MD) to project the right wavelength and intensity of light onto the treated retina. With the support of the Institut de la Vision in Paris and the team of Dr. Botond Roska at the Friedrich Miescher Institute in Basel, GenSight is investigating GS030 as therapy to restore vision in patients suffering from late-stage RP. 2021 Apr 28. L’ubérisation excite toutes les peurs, les fantasmes, les espoirs. Jean-François Sirinelli est professeur émérite d’histoire contemporaine à Sciences Po. Spécialiste de la Ve République et des mutations socioculturelles de la France contemporaine, il a publié de nombreux ouvrages qui ont fait date ...
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