82(4):731-9. What are the primary histologic findings of dengue? Setiati TE, Mairuhu AT, Koraka P, Supriatna M, Mac Gillavry MR, Brandjes DP, et al. [Medline]. Nat Med. Hoffmann AA, Montgomery BL, Popovici J, Iturbe-Ormaetxe I, Johnson PH, Muzzi F, et al. What is the disease progression of dengue? Semin Nephrol. Trans R Soc Trop Med Hyg. Schmidt AC. If cDNA was generated with a primer in one end of the virus genome it … Increasing rates of dengue infection by regions of the world. Suzanne Moore Shepherd, MD, MS, DTM&H, FACEP, FAAEM Professor of Emergency Medicine, Education Officer, Department of Emergency Medicine, Hospital of the University of Pennsylvania; Director of Education and Research, PENN Travel Medicine; Medical Director, Fast Track, Department of Emergency Medicine [Medline]. [Medline]. Zika Questions and Answers Updated October 2018 What is Zika? Courtesy of the World Health Organization (WHO). New strategy against Aedes aegypti in Vietnam. Liu-Helmersson J, Quam M, Wilder-Smith A, Stenlund H, Ebi K, Massad E, et al. World Health Organization. J Immunol. 2008 Dec. 51(6):812-3. 2016 Aug. 16 (8):882-3. [Medline]. Globally, 2. [Full Text]. Dengue is endemic in more than 125 countries in tropical and subtropical regions and causes an estimated 390 million infections annually worldwide, of which 96 million are clinically apparent [ 1 ]. 2006 Dec. 138(1-2):123-30. Hypotension usually is a late sign in children. [Medline]. What are the WHO criteria for the diagnosis of severe dengue (dengue hemorrhagic fever)? Curr Opin Infect Dis. 2008 Nov. 13(11):1328-40. Development of a live attenuated dengue virus vaccine using reverse genetics. WHO. Questions and Answers on Dengue Vaccines. Gubler DJ. Anker M, Arima Y. What is the role of arterial blood gas assessment in the diagnosis of dengue? PPS 2008 Practice Guidelines on DF/DHF answering relevant questions in the care of a child with dengue illness. WHO. Centers for Disease Control and Prevention (CDC). 2006 Oct. 19(5):429-36. Vaccine. What should I do if I suspect I have dengue? PLoS Negl Trop Dis. Family 2. [Medline]. An extensive list of all the the frequently asked questions in relation to dengue fever. 2009 May. 84(3):473-88. The Dengue antigen NS 1 is detected within 24 hours and lasts up to 9 days. Western Pac Surveill Response J. CDC traveler's health page. 353(9):877-89. Which factors affect the severity of dengue? Available at http://www.cdc.gov/Dengue/travelOutbreaks/. Which medications in the drug class Vaccines, Live, Viral are used in the treatment of Dengue? What are the symptoms of dengue fever and severe dengue? How do you get it? Pediatrics. How does the incidence of dengue vary by sex? Courtesy of the Centers for Disease Control and Prevention (CDC). Complication of dengue fever can give rise to a more severe form, called dengue hemorrhagic fever. Imported dengue--United States, 1997 and 1998. Wichmann O, Stark K, Shu PY, Niedrig M, Frank C, Huang JH. 26(4):283-90; discussion 291-2. How are fluid volume and blood pressure managed in severe dengue (dengue hemorrhagic fever)? Trung DT, Thao le TT, Hien TT, et al. Monath TP. Childhood memory 8. Historical place 11. Pediatr Blood Cancer. Dengue transmission cycle. 2010 Apr 15. 1993 Jul. [Medline]. Which lab tests should be performed in the workup of possible dengue? Trends Parasitol. [Medline]. [Full Text]. Dengue fever questions and rationale Download Here Free HealthCareMagic App to Ask a Doctor All the information, content and live chat provided on the site is intended to be for informational purposes only, and not a substitute for professional or medical advice. What is characteristic of the dengue outbreaks in Hawaii in the 21st century? [Medline]. 2008 Sep. 24(9):396-400. Vertical transmission of dengue. Am J Trop Med Hyg. 2008 Jul. 2013 Apr 25. Istúriz RE, Gubler DJ, Brea del Castillo J. Dengue and dengue hemorrhagic fever in Latin America and the Caribbean. It is estimated that there are over 50-100 million cases of dengue worldwide each year and 3 billion people living in dengue endemic countries. 2010 May 7. Dengvaxia. Interaction of dengue virus envelope protein with endoplasmic reticulum-resident chaperones facilitates dengue virus production. What are the differences between serotype 1 dengue (DENV-1) and serotype 2 dengue (DENV-2)? [Medline]. Singh N, Sharma KA, Dadhwal V, Mittal S, Selvi AS. Courtesy of the Centers for Disease Control and Prevention (CDC). Which medications in the drug class Volume Expanders are used in the treatment of Dengue? How to Prevent Getting Dengue Fever. Which lab findings suggest severe dengue (dengue hemorrhagic fever)? N Engl J Med. What is the economic burden of dengue infection in Southeast Asia? [Medline]. 40(11-12):993-4. Accident 7. [Medline]. Courtesy of Wikimedia Commons (https://commons.wikimedia.org/wiki/File:Aedes_aegypti.jpg; author Muhammad Mahdi Karim). 7:41697. 2014 Mar. 2007 Jan. 86(1):18-25. What are the characteristic lab findings in dengue? Blaney JE Jr, Durbin AP, Murphy BR, Whitehead SS. 181(9):5865-74. [Medline]. 2011 Apr. [Medline]. Which areas of South America are at highest risk for dengue? [Medline]. 2008 Jul. Mosquitocidal vaccines: a neglected addition to malaria and dengue control strategies. Larsen CP, Whitehead SS, Durbin AP. Top 10 Interview Questions and Best Answers Review these most frequently asked interview questions and sample answers, and then prepare your own responses based on your experience, skills, and interests. What are the manifestations of plasma leakage in dengue? 28(4):320-9. When is IV fluid administration indicated in the treatment of dengue? Domingo C, de Ory F, Sanz JC, Reyes N, Gascón J, Wichmann O, et al. Note that Dengue is around 11000 bases (ssRNA virus). Ten threats to global health in 2019. What are the benefits of travel surveillance for dengue? [Medline]. Dengue is … [Medline]. 496 (7446):504-7. Dengue is the most common arthropod-borne viral (arboviral) illness in humans. [Medline]. What is the role of vaccination in the prevention of dengue? What is the largest known epidemic of dengue? [Medline]. Dengue/Severe dengue frequently asked questions What is dengue fever and severe dengue? Successful establishment of Wolbachia in Aedes populations to suppress dengue transmission. Suzanne Moore Shepherd, MD, MS, DTM&H, FACEP, FAAEM Professor of Emergency Medicine, Education Officer, Department of Emergency Medicine, Hospital of the University of Pennsylvania; Director of Education and Research, PENN Travel Medicine; Medical Director, Fast Track, Department of … 2010 Apr. Emerg Infect Dis. 328(5979):745-8. Wills BA, Nguyen MD, Ha TL, Dong TH, Tran TN, Le TT, et al. Hanh TT, Hill PS, Kay BH, Quy TM. 1999 Apr 25. [Medline]. 2008 Nov. 79(5):678-84. For typical dengue fever, treatment is directed towards the relief of symptoms. Epidemiol Infect. Favorite rooms 9. What is the typical presentation of dengue? 83(4):308-14. However, no data on the … 2004 Apr. [Medline]. N Engl J Med. Michael Stuart Bronze, MD is a member of the following medical societies: Alpha Omega Alpha, American College of Physicians, American Medical Association, Association of Professors of Medicine, Infectious Diseases Society of America, Oklahoma State Medical Association, Southern Society for Clinical InvestigationDisclosure: Nothing to disclose. Lancet Infect Dis. Introduction Dengue fever (DF) is a climate-sensitive mosquito-borne viral infection that has emerged as a major public health burden. What is the role of guaiac testing in suspected dengue? Fever typically abates with the cessation of viremia. What is severe dengue (dengue hemorrhagic fever)? Travel 5. 2010 Jul 29. When … [Medline]. 2011 Mar. [Medline]. 2006 Jan. 74(1):142-7. [Medline]. There are 4 serotypes of the virus that Wilson ME, Chen LH. Erlanger TE, Keiser J, Utzinger J. [Medline]. 19(1):10-32. 2014. [Full Text]. Accessed: October 20, 2011. 2006 Dec. 15(4):223-8. What is the role of ultrasonography in the diagnose dengue? Courtesy of the Centers for Disease Control and Prevention (CDC). Dengue viral infections. Burden of symptomatic dengue infection in children at primary school in Thailand: a prospective study. [Medline]. William H Shoff, MD, DTM&H Former Director, PENN Travel Medicine; Former Associate Professor, Department of Emergency Medicine, Hospital of the University of Pennsylvania, University of Pennsylvania School of Medicine Sanjay S, Wagle AM, Au Eong KG. Beatty ME, Beutels P, Meltzer MI, et al. 1 Dengue Fever Frequently Asked Questions (FAQ) GENERAL QUESTIONS 1 June 2016 1. Dengue. The reemergence of Aedes aegypti in Arizona. The causes, symptoms, testing, prevention and treatment methods are discussed in detail. Phase I clinical evaluation of rDEN4Delta30-200,201: a live attenuated dengue 4 vaccine candidate designed for decreased hepatotoxicity. This website also contains material copyrighted by 3rd parties. Chen LC, Lei HY, Liu CC, Shiesh SC, Chen SH, Liu HS. These are known as DEN-1, DEN-2, DEN-3, DEN-4. Worldwide distribution of dengue in 2000. [Medline]. Available at https://www.who.int/emergencies/ten-threats-to-global-health-in-2019. In this decade it has expanded to new countries and from urban to rural areas. Shah I. Dengue and liver disease. What is the prevalence of thrombocytopenia in dengue? [Medline]. [Medline]. Darvin Scott Smith, MD, MSc, DTM&H Adjunct Associate Clinical Professor, Department of Microbiology and Immunology, Stanford University School of Medicine; Chief of Infectious Diseases and Geographic Medicine, Department of Internal Medicine, Kaiser Permanente Medical Group 2004 Oct. 80(948):588-601. Pediatr Infect Dis J. Wang E, Ni H, Xu R, Barrett AD, Watowich SJ, Gubler DJ. 2007 Nov 10. Books 4. What is the role of serum studies in the diagnosis of dengue? Insects. 2011 Feb. 84(2):200-7. de Macedo FC, Nicol AF, Cooper LD, Yearsley M, Pires AR, Nuovo GJ. [Medline]. Available at https://www.who.int/immunization/research/development/dengue_q_and_a/en/. 2008. The intended users of this document include primary … Choose the BEST answer. Economic impact of dengue illness in the Americas. MMWR Morb Mortal Wkly Rep. 2010 Jun 18. Jan 23 2014. [Full Text]. What is the mortality rate of dengue in the US? Crystalloid fluid resuscitation and standard DIC treatment are critical to the child's survival. Freedman DO, Weld LH, Kozarsky PE, Fisk T, Robins R, von Sonnenburg F. Spectrum of disease and relation to place of exposure among ill returned travelers. What are the limitations of vaccine in the prevention of dengue? Dengue and severe dengue fact sheet. Take it now! Kurane I, Innis BL, Nimmannitya S, Nisalak A, Meager A, Ennis FA. What are the clinical characteristics of severe dengue (dengue hemorrhagic fever)? [Full Text]. 1. 50(8):1135-43. 2005 Jan 4. What is the prevalence of dengue in Europe? [Medline]. 2010 Oct. 83(4):774-80. Infect Dis Clin North Am. A list of questions and answers has been formulated to address any concerns about Dengue Fever and preventive measures being taken in the Florida Keys. Dengue is a vector-borne disease transmitted by the bite of an infected mosquito. Impact of Dengue. What are the criteria used to classify a case as suspected or probable dengue? 2007 Apr. Dejnirattisai W, Jumnainsong A, Onsirisakul N, et al. Am J Trop Med Hyg. CDC. Viral hemorrhagic fever-induced acute kidney injury. It is caused by any one of four closely related dengue viruses (DENV 1, … Correlation of serum levels of macrophage migration inhibitory factor with disease severity and clinical outcome in dengue patients. [Medline]. Chen WS, Wong CH, Cillekens L. Dengue antibodies in a suburban community in Malaysia. Clinical features and pitfalls in the laboratory diagnosis of dengue in travellers. 90,000 U.S. doctors in 147 specialties are here to answer your questions or offer you advice, prescriptions, and more. Dengue disease severity in Indonesian children: an evaluation of the World Health Organization classification system. 379(2):196-200. [Medline]. Curr Infect Dis Rep. 2015 Jan. 17 (1):457. Chowell G, Torre CA, Munayco-Escate C, Suárez-Ognio L, López-Cruz R, Hyman JM. [Medline]. Kay B, Vu SN. Accessed: October 20, 2011. Am J Trop Med Hyg. Website 6. [Medline]. Bottieau E, Clerinx J, Van den Enden E, Van Esbroeck M, Colebunders R, Van Gompel A. J Clin Invest. [Medline]. Signs of early coagulopathy may be as subtle as a guaiac test that is positive for occult blood in the stool. Skip to content Tributes HI NOW Jobs Join Our Team Check Out 'n' Take Out Class of 2020 Advertise with Us … [Medline]. Comparison of three fluid solutions for resuscitation in dengue shock syndrome. Which physical findings are characteristic of severe dengue? Dejnirattisai W, Duangchinda T, Lin CL, Vasanawathana S, Jones M, Jacobs M, et al. Halstead SB, Heinz FX, Barrett AD, Roehrig JT. 2009 Sep. 65(1):42-8. [Medline]. 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What are neurologic manifestations of dengue? William H Shoff, MD, DTM&H is a member of the following medical societies: American College of Physicians, American Society of Tropical Medicine and Hygiene, International Society of Travel Medicine, Society for Academic Emergency Medicine, Wilderness Medical SocietyDisclosure: Nothing to disclose. [Medline]. Cross-reacting antibodies enhance dengue virus infection in humans. Lin CC, Huang YH, Shu PY, et al. 2005 Sep 1. [Full Text]. Dengue, acute infectious mosquito-borne fever that is temporarily incapacitating but rarely fatal. Diagn Mol Pathol. Global spread of dengue virus types: mapping the 70 year history. Immunopathogenesis of Dengue hemorrhagic fever. How does the transmission of dengue occur? 28(4):409-15. [Medline]. 2016 May. ESL Conversation Questions and Answers – 75 Topics 1. J Med Virol. Which activity modifications are beneficial during treatment of dengue? 2007 Jul 15. Through Dengue-Antigen-NS1, diagnoses of acute DV infection can be seen. What is the role of liver enzyme testing in the diagnosis of dengue? Check if you know enough about this deadly disease by taking this quiz. Restaurant 3. [Medline]. Dengue is an endemic problem in several countries including India. How long is the recovery process for patients with dengue? Drawing of Aedes aegypti mosquito. Restrepo BN, Ramirez RE, Arboleda M, Alvarez G, Ospina M, Diaz FJ. [Medline]. N Engl J Med. 37(4):681-3. [Medline]. Nature. What are the characteristic lab findings in dengue fever? [Medline]. What is a biological approach to reducing vector mosquitos and preventing dengue? 2007 Feb. 13(2):282-6. BMC Infect Dis. Which physical findings are characteristic of dengue fever? Available at http://www.who.int/topics/dengue/en/. Refining the global spatial limits of dengue virus transmission by evidence-based consensus. Climate Change and Aedes Vectors: 21st Century Projections for Dengue Transmission in Europe. Fever after a stay in the tropics: diagnostic predictors of the leading tropical conditions. Which lab techniques are used to confirm dengue infection? 23(7):849-56. 2(9):e300. All material on this website is protected by copyright, Copyright © 1994-2021 by WebMD LLC. When is oral rehydration indicated for the management of dengue? Green S, Rothman A. Immunopathological mechanisms in dengue and dengue hemorrhagic fever. 2007 Nov 29. [Medline]. Am J Trop Med Hyg. How frequently do outbreaks of severe dengue (dengue hemorrhagic fever) occur? 369(9571):1452-9. EBioMedicine. Worldwide distribution of dengue in 2003. Histologic, viral, and molecular correlates of dengue fever infection of the liver using highly sensitive immunohistochemistry. What are the symptoms of … [Medline]. Nature. Yadav SP, Sachdeva A, Gupta D, Sharma SD, Kharya G. Control of massive bleeding in dengue hemorrhagic fever with severe thrombocytopenia by use of intravenous anti-D globulin. Which medications are used for the treatment of dengue? 2. Which physical findings are characteristic of severe dengue (dengue hemorrhagic fever)? 14(1):121-40, ix. There are 4 serotypes of the virus that causes dengue. How does the incidence of dengue vary by age? There are four dengue virus (DENV) types (DENV-1, DENV-2, DENV-3, and DENV-4), all of which are capable of inducing severe disease (dengue hemorrhagic fever [DHF]/dengue shock syndrome [DSS]). 7:22. What are the causes of thrombocytopenia in dengue? [Medline]. Dengvaxia (dengue vaccine) [package insert]. [Medline]. Diagn Microbiol Infect Dis. 22 (3):138-46. Molecular and serologic markers of acute dengue infection in naive and flavivirus-vaccinated travelers. Dengue induces platelet activation, mitochondrial dysfunction and cell death through mechanisms that involve DC-SIGN and caspases. 2009 Oct. 46 Suppl 2:S20-4. How is a serum study performed in the diagnosis of dengue? [Medline]. Michael Stuart Bronze, MD David Ross Boyd Professor and Chairman, Department of Medicine, Stewart G Wolf Endowed Chair in Internal Medicine, Department of Medicine, University of Oklahoma Health Science Center; Master of the American College of Physicians; Fellow, Infectious Diseases Society of America; Fellow of the Royal College of Physicians, London What is the role of steroids in the treatment of dengue? Severe dengue is a potentially lethal complication which can develop from dengue infections. 2004 Feb. 10(2):129-30. Epidemiology of acute kidney injury in Latin America. [Medline]. [Full Text]. 2007 Apr 28. What are the signs and symptoms of dengue? [Medline]. [Medline]. What information about dengue should patients be given? How is circulatory failure characterized in the diagnostic criteria for severe dengue shock? Ojha A, Nandi D, Batra H, Singhal R, Annarapu GK, Bhattacharyya S, et al. Limjindaporn T, Wongwiwat W, Noisakran S, Srisawat C, Netsawang J, Puttikhunt C, et al. Locally acquired Dengue--Key West, Florida, 2009-2010. BMC Infect Dis. 2006. European Medicines Agency. Wrong treatment most common cause of dengue fatality. Southeast Asian J Trop Med Public Health. PLoS Negl Trop Dis. When autocomplete results are available use up and down arrows to review and enter to select. A successful management of dengue fever in pregnancy: report of two cases. Dengue, (pronounced DEN-ghee) is a tropical disease spread by mosquitoes. 2014 Dec 16. Dengue is the most common arthropod-borne viral (arboviral) illness in humans. [Full Text]. 2006 Spring. 356(3):763-8. Statler J, Mammen M, Lyons A, Sun W. Sonographic findings of healthy volunteers infected with dengue virus. World Health Organization. Coronavirus disease outbreak (COVID-2019), Coronavirus disease outbreak (COVID-19) ». Am J Trop Med Hyg. 2015 Sep 28. Where was the first clearly identified local transmission of dengue in the US? 2008 Oct-Dec. 26(4):377-80. Emerg Infect Dis. Test Description 1. How is dengue diagnosed and treated during pregnancy? Patrick B Hinfey, MD is a member of the following medical societies: American Academy of Emergency Medicine, Wilderness Medical Society, American College of Emergency Physicians, Society for Academic Emergency MedicineDisclosure: Nothing to disclose. 113(7):946-51. Virology. [Medline]. Viral Immunol. Chaterji S, Allen JC Jr, Chow A, Leo YS, Ooi EE. 63(3):49-54. 2002 Apr. Med J Malaysia. What are characteristics of the Aedes mosquito species that transmit dengue? 357(22):2222-5. Evaluation of the NS1 rapid test and the WHO dengue classification schemes for use as bedside diagnosis of acute dengue fever in adults. Courtesy of the Centers for Disease Control and Prevention (CDC). What is the principal mosquito vector for dengue in the US? Dengue in pregnancy. Dengue infections during pregnancy: a case series from Sri Lanka and review of the literature. [Medline]. 370(9599):1644-52. Health economics of dengue: a systematic literature review and expert panel's assessment. 11 (5):951-62. [Medline]. [Full Text]. 5 (4):991-1000. [Medline]. 91 (30):349-64. Lancet. Nosocomial acquisition of dengue. Teves Maria A. Cost of dengue cases in eight countries in the Americas and Asia: a prospective study. Worldwide distribution of dengue in 2005. [Medline]. Available at https://www.ema.europa.eu/en/medicines/human/EPAR/dengvaxia. 2011 Aug 24. Dengue fever is caused by a virus, and there is no specific medication or antibiotic to treat it. What are the characteristic lab findings in severe dengue (dengue hemorrhagic fever)? Courtesy of the Centers for Disease Control and Prevention (CDC). Characteristic of dengue disease in Taiwan: 2002-2007. Courtesy of the Centers for Disease Control and Prevention (CDC) (https://www.cdc.gov/dengue/areaswithrisk/around-the-world.html). McArthur JH, Durbin AP, Marron JA, Wanionek KA, Thumar B, Pierro DJ, et al. Dengue: defining protective versus pathologic immunity. Lima EQ, Nogueira ML. What is dengue fever? What happens if severe dengue (dengue hemorrhagic fever) is left untreated? This child's capillary refill at 6 seconds was delayed well beyond a normal duration of 2 seconds. Single rapid TaqMan fluorogenic probe based PCR assay that detects all four dengue serotypes. 66(4):524-8. Which specialists should be consulted for the management of dengue? Courtesy of the Centers for Disease Control and Prevention (CDC). What is the antiviral treatment for dengue? What are the signs and symptoms of severe dengue (dengue hemorrhagic fever)? The global distribution and burden of dengue. 2008 Nov. 92(6):1377-90, x. What is the role of hematocrit level measurement in the diagnosis of dengue? [Medline]. Santhosh VR, Patil PG, Srinath MG, Kumar A, Jain A, Archana M. Sonography in the diagnosis and assessment of dengue Fever. 2009 Sep. 8(9):1139-42. What is the role of chest radiography in the diagnosis of dengue? [Full Text]. Science. Which imaging studies are used in the evaluation of suspected dengue? 2000 Mar. Male-female differences in the number of reported incident dengue fever cases in six Asian countries. What are the primary hosts for the transmission of dengue? [Medline]. Zika is an infectious disease caused by the Zika virus, which is primarily transmitted to people by … [Full Text]. [Medline]. Engelthaler DM, Fink TM, Levy CE, Leslie MJ. Delayed capillary refill may be the first sign of intravascular volume depletion. Which physical findings are characteristic of dengue shock syndrome? [Medline]. What can be done to reduce the risk of acquiring dengue. 2008 Sep 24. Available at http://www.who.int/mediacentre/factsheets/fs117/en/. What should be the focus of medical history in suspected dengue? Dengue and yellow fever--challenges for the development and use of vaccines. How is the breeding of vector mosquitos reduced for the prevention of dengue? What is the prevalence of rash due to dengue infection and how is it characterized? What is the role of plasma leakage in the pathophysiology of severe dengue (dengue hemorrhagic fever)? 13. Clin Infect Dis. Malavige GN, Fernando S, Fernando DJ, Seneviratne SL. 2008 Oct. 102(10):1011-6. What is the global incidence of dengue outbreaks in 2014? Which vectors for dengue are present in the US and what is their geographic range? Dengue and Dengue Hemorrhagic Fever: Questions and Answers (en español ) Q. [Medline]. Dengue is common in more than 100 countries around the world. 2006 Aug. 94(2):131-2. Lancet. Am J Trop Med Hyg. Global map of dengue risk. 80(5):846-55. 2 (2):17-23. Available at http://www.who.int/topics/dengue/en/. 92(1):111-5. 2008 Sep. 36(7):413-7. No, dengue is not contagious and cannot be transmitted from person to person. 12th Annual Conference on Vaccine Research. When are patients with severe dengue (dengue hemorrhagic fever) discharged from the hospital? Dengue fever is typically a self-limited disease with a mortality rate of less than 1% when detected early and with access to proper medical care. MMWR Morb Mortal Wkly Rep. 2000 Mar 31. Shepard DS, Coudeville L, Halasa YA, Zambrano B, Dayan GH. Swiftwater, PA: Sanofi Pasteur, Inc. May 2019. Accessed: October 14, 2011. When was the first reported dengue epidemic? When is guaiac testing indicated in the diagnosis of suspected dengue? Aedes albopictus. [Medline]. 1997. Dengue is transmitted to people through insect bites. J Clin Imaging Sci. High levels of interferon alpha in the sera of children with dengue virus infection. Bull World Health Organ. Joseph Domachowske, MD Professor of Pediatrics, Microbiology and Immunology, Department of Pediatrics, Division of Infectious Diseases, State University of New York Upstate Medical University, Joseph Domachowske, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Pediatrics, American Society for Microbiology, Infectious Diseases Society of America, Pediatric Infectious Diseases Society, and Phi Beta Kappa, Hagop A Isnar, MD, FACEP Department of Emergency Medicine, Crouse Hospital, Hagop A Isnar, MD, FACEP is a member of the following medical societies: American College of Emergency Physicians, American Medical Association, and Society for Academic Emergency Medicine, Thomas M Kerkering, MD Chief of Infectious Diseases, Virginia Tech, Carilion School of Medicine, Roanoke, Virginia, Thomas M Kerkering, MD is a member of the following medical societies: Alpha Omega Alpha, American College of Physicians, American Public Health Association, American Society for Microbiology, American Society of Tropical Medicine and Hygiene, Infectious Diseases Society of America, Medical Society of Virginia, and Wilderness Medical Society, Deborah Sentochnik, MD Consulting Staff, Department of Internal Medicine, Division of Infectious Disease, The Mary Imogene Bassett Hospital, Deborah Sentochnik, MD is a member of the following medical societies: American College of Physicians, Infectious Diseases Society of America, and Medical Society of the State of New York, Russell W Steele, MD Head, Division of Pediatric Infectious Diseases, Ochsner Children's Health Center; Clinical Professor, Department of Pediatrics, Tulane University School of Medicine, Russell W Steele, MD is a member of the following medical societies: American Academy of Pediatrics, American Association of Immunologists, American Pediatric Society, American Society for Microbiology, Infectious Diseases Society of America, Louisiana State Medical Society, Pediatric Infectious Diseases Society, Society for Pediatric Research, and Southern Medical Association, Francisco Talavera, PharmD, PhD, Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference, Disclosure: Medscape Reference Salary Employment, Mary L Windle, PharmD, Adjunct Associate Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference. Am J Trop Med Hyg. When is typing and crossmatching of blood indicated for the diagnosis of dengue? [Medline]. Recent studies point in the direction of answers to these questions.